Using proven standard components, Collette (part of GEA Pharma Systems
group) can supply both simplicity and flexibility in pharmaceutical plant
design. User-selected process and drying options, control systems and liquid
recovery units combine in a system to meet process requirements exactly. This
approach ensures that qualification and validation work can be kept to a
minimum and secures successful results.
As One-Pot (or Single Pot) Processing builds upon the well established high
shear granulation technology, all process options available for the UltimaGral™
range are also available for the UltimaPro™ range.
Through-the-wall configuration
Through the wall offers
the best option in terms of cleanliness, maintenance and explosion protection.
The Through-the wall configuration provides a sealed separation between
technical and GMP space by the machine itself. This offers a clear containment
concept including
explosion area separation that fulfills the latest
requirements like ATEX.
By keeping technical components out of the process
room, the equipment is much easier to clean. Maintenance is carried out from
the technical area, reducing the need for the
maintenance engineer to work
in a GMP area. This reduces downtime and the risk of contamination. For ATEX,
the design allows the technical area to be classified as safe.
Loading
Depending on the layout of the production
area, several options for loading the powders are available. When the
processing room is sufficiently high, gravity loading is applicable, using post
hoists to lift the IBC on top of the UltimaPro™. Alternatively gravity loading
with the IBC located on a docking station on the floor above the machine is
possible if a multiple floor installation is preferred. In height-restricted
areas however, vacuum loading can be used. In this case the product is sucked
into the processing vessel from an IBC located close to the machine on the
floor.
Moveable Head
The UltimaPro™ can be equipped with a
‘Movable Head’ to enhance flexibility.
This feature allows operators to
lower the closed bowl to enable better accessibility and easy loading. The
closed bowl can also be raised for dust free discharging.
This option is
extremely useful in height-constrained processing areas
Binder solution addition
A range of binder addition
systems is available to give the optimum binder liquid droplet size for an even
distribution throughout the powder mass, for different viscosities.
The
liquid is transferred to the mixing bowl using a peristaltic pump or pressure
vessel, while the rate and amount is controlled by a loss in weight system or a
mass flow meter.