After a thorough testing period and machines sold to some of the major multinational pharmaceutical companies impressed with the technology, Collette will now proudly present CONSIGMA™, its new Continuous High Shear Granulation and Drying system, at the coming Interpack show in Düsseldorf, Germany.
CONSIGMA™ is fully capable of doing particle design as well as mimicking any traditional batch granulation process results, this with a much higher and consistent quality, owing to its continuous production set up and its ’risk based approach’ to GMP.
The granules have generally a better intra-granular porosity with better compressibility characteristics. Forget about rejects in granulation or tableting: the granules produced will make your tablet presses run more efficiently, at maximum speed with hardly any weight adjustments required.
Optional inline measurement of Critical Quality Attributes fed back to the control system will allow for continuous ’real time’ quality assurance according to GAMP5.
One CONSIGMA™ can run 500g in R&D, but can also run clinical trial, launch size, and any production size batches. There is no process scale-up anymore as time is the only relevant factor in a continuous process. Your development time and cost can be reduced drastically allowing you to bring products to market much faster.
With its light weight, ultra small size (1/4 of a classic granulation line) and modular construction it fits perfectly in every R&D department or an existing tablet production room. No need any more to change the building, just wheel it in, connect the power and air supply, and after a short and easy start-up period off you go. Installation time and cost are reduced to a fraction of the current benchmark .
By avoiding high peak energy periods and running at a continuous low energy consumption, CONSIGMA™ can power your business without damaging our planet.
Suddenly the 6 sigma quality level is within reach. CONSI6MA™ is the name, developed by Collette, Masters in Granulation Technology.