Contained Single Pot Processor
Many active ingredients of oral solid dosage forms are highly active and potent compounds that require special care during production to avoid exposure of the operators to the drug. In recent years, the focus of operator protection has shifted from cumbersome personal protection equipment (such as ‘moonsuits’) to contained equipment to avoid contact between operator and product. The goal is to allow the operators to work in shirt sleeves by introducing containment measures in the production equipment that reduce the airborne exposure levels of the product to safe levels.
GEA Pharma Systems nv – Collette™ - recommands the ULTIMAPRO™, Single Pot Processor (One-Pot Processor), for contained granulation and drying of highly potent compounds.
The concept of a Single Pot Processor in itself already ensures contained processing by avoiding product transfers and executing the unit operations of mixing, granulation and drying in one machine. Additionally, the ULTIMAPRO™ can be equipped with several features to optimise the containment of toxic products:
- Product feed and discharge valve can be equipped with Buck® high containment split butterfly valves,
- and upon the request of the customer, even with isolator boxes.
- A sampling valve that allows the operator to take samples during the process without having to stop the machine, open the bowl, or even open a port in the lid, can be integrated into the processing chamber and adapted to different containment levels.
- The sample container is completely contained allowing the sample to be transported to the QC lab without exposure to the atmosphere.
The concept of containment not only applies to the production area. When working with organic solvents, recovery and containment of these solvents is as important as containment of the product itself. The ULTIMAPRO™ is equipped with a very efficient recovery system that can recover more than 99% of the used solvents.
Even for cleaning, the concept of containment is applied. The ULTIMAPRO™ can be supplied with a wide range of washing-in-place and fully automated cleaning-in-place options. CIP features include spray nozzles adapted for most adequate cleaning of product feed, product filter, bowl, lid and discharge valve (for example retractable spray nozzles for the lid). Even downstream equipment such as a mill can be incorporated in the CIP system.
Single Pot technology can be tested in the Process Development Center of GEA Pharma Systems nv – Collette™ in Wommelgem, Belgium ... Read more about Single Pot Processing
Business Contact:
Wim Van der Goten
Sales Director
GEA Pharma Systems nv - Collette™
BE-2160, Wommelgem, Belgium
Office: +32 (0) 3 350 12 39 / Fax: +32 (0) 3 353 20 55,
Email: wim.vandergoten@geagroup.com
Press Contact:
Kris De Baere
Marketing Manager
GEA Pharma Systems
Office: +32 (0) 3 350 12 41, Mobile: + 32 (0) 473 73 19 45
Email: kris.debaere@geagroup.com